The questions are divided into the following catagories;

• General Information
• Diagnosis, Diagnostic Procedures, & Other Tests
• Treatment
• Related Disorders
• Other

Introduction
1. What is chronic lymphocytic leukemia (CLL)?
2. Can CLL be cured?
3. Are there other types of leukemia?
4. Are there subgroups of CLL?
5. How common is CLL?
6. What causes CLL?
7. Is CLL hereditary?
8. What are the stages of CLL?
9. What is the survival outlook for people with CLL?
10. What is "smoldering" CLL?

11. How is CLL diagnosed?
12. Should I seek a second opinion?
13. What are the blood count basics in CLL?
14. What do laboratory reference ranges mean?
15. What is the difference between percentage of lymphocytes and absolute lymphoycyte count (ALC)?
16. When do neutrophil counts become a problem?
17. When do platelet counts become a problem?
18. What are smudge cells?
19. What are immunoglobulins?
20. What questions should I ask in early visits with my hematologist?
21. What is flow cytometry?
22. What is polymerase chain reaction (PCR)?
23. What is the significance of IgV_H gene mutational status in CLL?
24. What is the significance of CD38 in CLL?
25. What is the significance of bcl-2 in CLL?
26. Will I need a bone marrow biopsy and how is it performed?
27. What information is detected in a bone marrow biopsy and aspirate?
28. What is the significance of beta-2-microglobulin in CLL?
29. What is fluorescence in situ hybridization (FISH)?
30. What does trisomy mean?
31. What are some of the main prognostic indicators in CLL?
32. What is tissue typing?
33. What is DiSC assay?

34. Should I start treatment as soon as possible?
35. What are the criteria for starting treatment?
36. How is CLL treated?
37. What drugs are used in treating CLL?
38. What questions should I ask prior to chemotherapy?
39. What side effects should I expect from chemotherapy?
40. Where in the CLL treatment plan does transplantation fit?
41. Should early stage patients have stem cells harvested and stored for future autologous transplant?
42. What is a mini-transplant?
43. What is a peripheral blood stem cell transplant (PBSCT)?
44. What is a cord blood transplant?
45. What is leukapheresis?
46. What about alternative/complementary therapies?
47. Is additional vitamin C recommended for people with CLL?
48. What is a neutroprenic diet?
49. What medical centres specialize in treating CLL?
50. What are clinical trials?
51. What constitutes a remission in CLL?
52. What is minimal residual disease (MRD)?

53. Does CLL lead to other forms of cancer?
54. What is the difference between CLL and lymphoma?
55. What is small lymphocytic lymphoma (SLL)?
56. What is hairy cell leukemia (HCL)?
57. What is prolymphocytic leukemia (PLL)?
58. What is Richter's syndrome?
59. What is mantle cell lymphoma (MCL), and is it related to CLL?
60. Is there a connection between shingles and CLL?
61. What is autoimmune hemolytic anemia (AIHA)?
62. What is idiopathic thrombocytopenic purpura (ITP)?
63. What causes night sweats in CLL?

64. How will CLL affect my normal activities?
65. Should people with CLL stop donating blood?
66. What are some of the dental considerations in CLL?
67. What are some of the terminal aspects of CLL?
68. What should I tell children?
69. What should I tell colleagues?
70. How may I be in touch with other CLL patients?
71. What are some of the leukemia-related organizations?