What is the difference between CLL and lymphoma?
CLL and the other leukemias are primary disorders of the bone marrow, whereas, the lymphomas are malignant disorders that arise in the lymphoid tissue, most often showing up as solid tumors in nodes found throughout the body.
There are two broad groups of lymphomas: the non-Hodgkin's lymphomas (NHL) and Hodgkin's disease (Hodgkin's lymphoma). Like the leukemias, non-Hodgkin's and Hodgkin's lymphomas are categorized into several sub-types. Classification of the lymphomas is a controversial area that is undergoing evolution. Following is a modified version of the Revised European American Lymphoma (REAL) Classification:
Indolent Non-Hodgkin's Lymphomas
- Follicle center cell lymphoma, follicular
- Grade I follicular small cleaved cell
- Grade II follicular mixed
- Diffuse small cleaved cell
- Diffuse small lymphocytic lymphoma
- Marginal zone lymphoma
- MALT (extranodal)
- Monocytoid B-cell lymphoma (nodal)
- Splenic lymphoma with villous lymphocytes
- Mycosis fungoides/Sezary syndrome
Aggressive Non-Hodgkin's Lymphomas
- Diffuse large cell lymphoma (includes diffuse mixed cell, diffuse large cell, immunoblastic)
- Burkitt's lymphoma/diffuse small non cleaved cell lymphoma
- Lymphoblastic lymphoma
- CNS lymphoma
- Adult T-cell lymphoma
- Mantle cell lymphoma
- Post-transplantation lymphoproliferative disorder
- AIDS-related lymphoma
- True histiocytic lymphoma
- Primary effusion lymphoma
Hodgkin's Disease
- Lymphocyte predominance
- Nodular sclerosis
- Mixed cellularity
- Lymphocyte depletion